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The Endocannabinoid System

In recent years, CBD has emerged as an amazing therapeutic compound that has gained immense attention from people around the world.  The primary source of CBD or other beneficial phytocannabinoids is Cannabis Sativa plant.

Cannabis has two main phytocannabinoids that are CBD or cannabidiol and THC or tetrahydrocannabinol.  Unlike THC, CBD is safe and non-psychoactive as it cannot cause intoxication. Phytocannabinoids offer exceptional health benefits because of their ability to interact with the human body. Research has shown that CBD can be helpful in alleviating chronic pain and inflammation, memory, cognitive function, hormonal disbalance, mood, and other related problems. Are you also wondering how CBD could be such a cure-all substance?

The answer lies in the way it interacts with the body. CBD engages the endocannabinoid system (ECS) that is spread all across the body. If you are unfamiliar with ECS, read on to know more about it. 

The Endocannabinoid System 

The endocannabinoid system is a biological system that was initially discovered by an Israeli scientist, Raphael Mechoulam. Previously, scientists could not figure out the exact neurotransmitter functionality. Mechoulam jumpstarted the medical revolution which has transformed the debate around cannabis and the lives of so many people. The endocannabinoid system works by the production of Endocannabinoid by the lipid membranes of the cells. These chemicals bind to the receptors that are present throughout the peripheral and central nervous systems. ECS is responsible for neuromodulation that helps the body in performing the physiological function. It has a significant effect on:

  • Chronic pain
  • Muscle formation
  • Cardiovascular system function
  • Mood
  • Appetite and digestion
  • Motor control
  • Sleep
  • Metabolism
  • Learning and memory
  • Skin and nerve function
  • Inflammation and other immune system responses
  • Bone remodeling and growth
  • Liver function
  • Reproductive system function
  • Stress

The endocannabinoid system is made up of endocannabinoid, endocannabinoid receptors, and degradation enzymes. Let’s take a detailed look at each of these. 

Endocannabinoid Receptors

Endocannabinoid Receptors are present throughout the body, including the central nervous system, peripheral nervous system, immune cells, and all other organs of the body. There are varieties of Endocannabinoid receptors, but the most common are CB1 and CB2. CB1 receptors are concentrated in the CNS, fat cells, musculoskeletal tissues, immune cells, and reproductive tract. The distribution of CB1 receptors shows the importance of endocannabinoid system functionality. CB1 receptors can have a significant effect on nausea, appetite, pain, mood, cognitive function, and inflammation. 

CB2 receptors are densely concentrated in the immune system, including T and B lymphocytes and macrophages, along with the cells of the kidney, liver, and spleen. The human skin houses a considerable number of CB2 receptors. The primary function is the intermediation of inflammation and immunomodulation. Research suggests that CB2 receptors play a crucial role in maintaining bone density. 

Endocannabinoid Neurotransmitters 

Endocannabinoid Neurotransmitters or Endogenous cannabinoids are produced only when the body requires them instead of being stored in the cells and released on demand. Physiological stress such as pain, injury, illness, and inflammation are the most common triggers for the production of endocannabinoid. They are also produced to maintain homeostasis in the body. Two main endocannabinoids produced by the body are anandamide and 2-AG. These molecules interact with the CB1 and CB2 receptors to carry out the desired physiological functions.

Degradation Enzymes

The endocannabinoid molecules are destined to be degraded when they are no longer needed by the body. Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) are produced to degrade anandamide and 2-AG, respectively. 

Phytocannabinoids and ECS  

CBD is the most famous therapeutic phytocannabinoid that has shown to be quite helpful in relieving the symptoms of several health issues. CBD is an antagonist of both CB1 and CB2 receptors with low to moderate binding affinity for each of these receptors.  Research has shown that CBD also has a modulatory effect on the endocannabinoid system.  It can bind to the fatty acid binding proteins to reduce or slow down the degradation of FAAH to promote the reuptake of anandamide and enhance its activity.  Not only this, CBD can also interact with the 5-HTA1 serotonin receptors to boost the uptake of serotonin and stabilize mood.

THC is a partial agonist of both CB1 and CB2 receptors, but it has a strong affinity for the CB1 receptors. A controlled quantity of THC is quite helpful in reducing pain, intraocular pressure, and insulin sensitivity. Since THC can form stronger bonds with CB1, it can cause intoxication and a long list of potential side effects. A combination of CBD and THC can cause reduced intoxication so that the patient can experience maximum health benefits of tetrahydrocannabinol. 

In addition to THC and CBD, many other phytocannabinoids, including cannabichromene, cannabigerol, tetrahydrocannabivarin, and Cannabidoil, could also be helpful for keeping the body at its best state. More research is required to know how these compounds can work in the body. However, we already know that all these phytocannabinoids, along with other nutrients such as terpenes, flavonoids, and healthy fatty acids work synergistically to produce the entourage effect. 

Clinical Endocannabinoid Deficiency 

CECD or clinical Endocannabinoid deficiency is considered to be a disease caused by the lack of endogenous cannabinoids. The concept of CECD was first introduced in 2004, and it is thought to be the potential reason behind many health conditions with no visible cause. Diseases such as migraine, fibromyalgia, Crohn’s disease, and irritable bowel syndrome could be because of endocannabinoids’ underproduction. Even though CBD may not be able to directly bind to the receptors but it can boost the uptake of the endocannabinoids. By inhibiting the function of FAAH, CBD can reduce the degradation of the endogenous cannabinoids, so even if the cells do not produce enough endocannabinoids, the ones already produced can serve the purpose.